李伟忠实验室

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Project Highlights

Genome Medicine：Identification of a cytokine-dominated immunosuppressive class in squamous cell lung carcinoma with implications for immunotherapy resistance

BMC：Deep learning-based six-type classifier for lung cancer and mimics from histopathological whole slide images: a retrospective study

PCM：Cytokine storm promoting T cell exhaustion in severe COVID-19 revealed by single cell sequencing data analysis

GPB：MicroPhenoDB Associates Metagenomic Data with Pathogenic Microbes, Microbial Core Genes, and Human Disease Phenotypes

Bioinformatics Platforms

PRECISION MEDICINE Big Data Analysis Community Platform

Biomedical Data Analysis Platform

PSISearch2D

Bioinformatics databases

scMoresDB

MicroPhenodb

ncRNAVar

ncRPheno

Grants

主持2021年国家重点研发计划（数字化细胞参照系研究、建设与示范应用）项目“多器官细胞全息图谱建设与疾病诊疗应用 ”（423万，2021-2024）

主持2016年国家重点研发计划（精准医学重点专项）课题“精准医学大数据的整合与注释”（500万，2016-2020年）

主持国家自然科学基金面上项目“组学数据反向检索（2018-2019年）

承担国家重点研发计划课题“精准医学大数据分析应用方法体系”（2018-2021年）

主持广东省自然科学基金项目：光镜图像中胚胎细胞的人工智能识别方法与胚胎发育无创评估系统（2021–2023）

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Recent Publications

Yang M, Lin C, Wang Y, Chen K, Zhang H, Li W. Identification of a cytokine-dominated immunosuppressive class in squamous cell lung carcinoma with implications for immunotherapy resistance. Genome Med. 2022 Jul 8;14(1):72. doi: 10.1186/s13073-022-01079-x. PMID: 35799269; PMCID: PMC9264601.

Yang M, Lin C, Wang Y, Chen K, Han Y, Zhang H, Li W. Cytokine storm promoting T cell exhaustion in severe COVID-19 revealed by single cell sequencing data analysis. Precis Clin Med. 2022 May 23;5(2):pbac014. doi: 10.1093/pcmedi/pbac014. PMID: 35694714; PMCID: PMC9172646.

Chen Y, Yang H, Cheng Z, Chen L, Peng S, Wang J, Yang M, Lin C, Chen Y, Wang Y, Huang L, Chen Y, Li W, Ke Z. A whole-slide image (WSI)-based immunohistochemical feature prediction system improves the subtyping of lung cancer. Lung Cancer. 2022 Jan 10;165:18-27. doi: 10.1016/j.lungcan.2022.01.005. Epub ahead of print. PMID: 35065344.

Yang H, Chen L, Cheng Z, Yang M, Wang J, Lin C, Wang Y, Huang L, Chen Y, Peng S, Ke Z, Li W. Deep learning-based six-type classifier for lung cancer and mimics from histopathological whole slide images: a retrospective study. BMC Med. 2021 Mar 29;19(1):80. doi: 10.1186/s12916-021-01953-2. PMID: 33775248; PMCID: PMC8006383.

Zhang W, Zeng B, Lin H, Guan W, Mo J, Wu S, Wei Y, Zhang Q, Yu D, Li W, Chan GC. CanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effects. Oncoimmunology. 2021 Jul 16;10(1):1944553. doi: 10.1080/2162402X.2021.1944553. PMID: 34345532; PMCID: PMC8288037.

Yao G, Zhang W, Yang M, Yang H, Wang J, Zhang H, Wei L, Xie Z, Li W. MicroPhenoDB Associates Metagenomic Data with Pathogenic Microbes, Microbial Core Genes, and Human Disease Phenotypes. Genomics Proteomics Bioinformatics. 2020 Dec;18(6):760-772. doi: 10.1016/j.gpb.2020.11.001. Epub 2021 Jan 6. PMID: 33418085; PMCID: PMC8377004.

Zhang W, Zeng B, Yang M, Yang H, Wang J, Deng Y, Zhang H, Yao G, Wu S, Li W. ncRNAVar: A Manually Curated Database for Identification of Noncoding RNA Variants Associated with Human Diseases. J Mol Biol. 2021 May 28;433(11):166727. doi: 10.1016/j.jmb.2020.166727. Epub 2020 Dec 1. PMID: 33275967.

Zhang W, Yao G, Wang J, Yang M, Wang J, Zhang H, Li W. ncRPheno: a comprehensive database platform for identification and validation of disease related noncoding RNAs. RNA Biol. 2020 Jul;17(7):943-955. doi: 10.1080/15476286.2020.1737441. Epub 2020 Mar 26. PMID: 32122231; PMCID: PMC7549653.

Yang M, Zhang W, Yao G, Zhang H, Li W. Combined alignments of sequences and domains characterize unknown proteins with remotely related protein search PSISearch2D. Database (Oxford). 2019 Jan 1;2019:baz092. doi: 10.1093/database/baz092. PMID: 31317184; PMCID: PMC6637259.

Bioinformatics Laboratory for Precision Medicine