佛山市普世医学科技有限责任公司

Bioinformatics Laboratory for Precision Medicine

Project Highlights

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Genome Medicine Identification of a cytokine-dominated immunosuppressive class in squamous cell lung carcinoma with implications for immunotherapy resistance
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Deep learning-based six-type classifier for lung cancer and mimics from histopathological whole slide images: a retrospective study
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Cytokine storm promoting T cell exhaustion in severe COVID-19 revealed by single cell sequencing data analysis
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MicroPhenoDB Associates Metagenomic Data with Pathogenic Microbes, Microbial Core Genes, and Human Disease Phenotypes

Bioinformatics Platforms

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PRECISION MEDICINE Big Data Analysis Community Platform
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Biomedical Data Analysis Platform
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PSISearch2D

Bioinformatics databases

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scMoresDB
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MicroPhenodb
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ncRNAVar
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ncRPheno

Grants

Recent Publications

   Minglei Yang, Chenghao Lin, Yanni Wang, Kang Chen, Yutong Han, Haiyue Zhang, Weizhong Li#, Cytokine storm promoting T cell exhaustion in severe COVID-19 revealed by single cell sequencing data analysis, Precision Clinical Medicine, Volume 5, Issue 2, June 2022.
   Chen Y, Yang H, Cheng Z, Chen L, Peng S, Wang J, Yang M, Lin C, Chen Y, Wang Y, Huang L, Chen Y, Li W#, Ke Z#. A whole-slide image (WSI)-based immunohistochemical feature prediction system improves the subtyping of lung cancer. Lung Cancer. 2022 Jan 10.
   Yang H, Chen L, Cheng Z, Yang M, Wang J, Lin C, Wang Y, Huang L, Chen Y, Peng S, Ke Z#, Li W#. Deep learning-based six-type classifier for lung cancer and mimics from histopathological whole slide images: a retrospective study. BMC Med. 2021 Mar 29;19(1):80. PMID: 33775248.
   Zhang W#, Zeng B, Lin H, Guan W, Mo J, Wu S, Wei Y, Zhang Q, Yu D#, Li W#, Chan GC#. CanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effects. Oncoimmunology. 2021 Jul 16.
   Guocai Yao, Wenliang Zhang, Minglei Yang, Huan Yang, Jianbo Wang, Haiyue Zhang, Lai Wei, Zhi Xie, Weizhong Li. MicroPhenoDB Associates Metagenomic Data with Pathogenic Microbes, Microbial Core Genes, and Human Disease Phenotypes. 2021
   Wenliang Zhang, Binghui Zeng, Minglei Yang, Huan Yang, Jianbo Wang, Yongjie Deng, Haiyue Zhang, Guocai Yao, Song Wu and Weizhong Li. ncRNAVar: A Manually Curated Database for Identification of Noncoding RNA Variants Associated with Human Diseases. 2020
   Wenliang Zhang, Guocai Yao, Jianbo Wang, Minglei Yang, Jing Wang, Haiyue Zhang, Weizhong Li. ncRPheno: a comprehensive database platform for identification and validation of disease related noncoding RNAs. 2020 Mar
   Minglei Yang, Wenliang Zhang, Guocai Yao, Haiyue Zhang, Weizhong Li. Combined alignments of sequences and domains characterize unknown proteins with remotely related protein search PSISearch2D. 2019 Jun

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